The role of dopamine in reward and pleasure behaviour : review of data from preclinical research
Identifieur interne : 002A98 ( Main/Exploration ); précédent : 002A97; suivant : 002A99The role of dopamine in reward and pleasure behaviour : review of data from preclinical research
Auteurs : R. A. Bressan [Brésil] ; J. A. Crippa [Brésil]Source :
- Acta psychiatrica scandinavica. Supplementum [ 0065-1591 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objective: The purpose of this article is to review some of the basic aspects of the dopaminergic system and its role in reward and pleasure behaviour. We also discuss the association between dopamine and unpleasant symptoms that are commonly found in neuropsychiatric disorders and may also be side-effects of neuroleptic drugs. Method: A computer-based search of the literature, augmented by extensive bibliography-guided article reviews, were used to find basic information on the dopamine and the reward systems, and symptoms such as dysphoria, anhedonia and depression. Results: Central dopaminergic neurotransmission is complex, having multiple actions at each level of the mesocorticolimbic reward pathway. The role of dopamine in the reward process was classically associated with the ability to experience pleasure; recent data suggest a more motivational role. Dysfunction of the dopamine transmission in the reward circuit is associated with symptoms such as anhedonia, apathy and dysphoria found in several neuropsychiatric disorders, including Parkinson's disease, depression, drug addiction, and neuroleptic-induced dysphoria. Conclusion: Viewing the dysfunctions of the reward pathways within a broader spectrum and exploring its complex relations with the dopaminergic transmission may help understand the pathophysiology of these neuropsychiatric disorders and lead to a rational development of novel treatments.
Affiliations:
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Crippa</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Psychiatry and Psychological Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP-RP)</s1><s2>Sao Paulo, SP</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0303487</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0303487 INIST</idno><idno type="RBID">Pascal:05-0303487</idno><idno type="wicri:Area/PascalFrancis/Corpus">000903</idno><idno type="wicri:Area/PascalFrancis/Curation">000420</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000762</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000762</idno><idno type="wicri:doubleKey">0065-1591:2005:Bressan R:the:role:of</idno><idno type="wicri:Area/Main/Merge">002E30</idno><idno type="wicri:Area/Main/Curation">002A98</idno><idno type="wicri:Area/Main/Exploration">002A98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The role of dopamine in reward and pleasure behaviour : review of data from preclinical research</title><author><name sortKey="Bressan, R A" sort="Bressan, R A" uniqKey="Bressan R" first="R. A." last="Bressan">R. A. Bressan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Interdisciplinary Lab of Neuroimaging and Cognition (LiNC), Department of Psychiatry, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo, SP</s2><s3>BRA</s3><sZ>1 aut.</sZ></inist:fA14><country>Brésil</country><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Crippa, J A" sort="Crippa, J A" uniqKey="Crippa J" first="J. A." last="Crippa">J. A. Crippa</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Psychiatry and Psychological Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP-RP)</s1><s2>Sao Paulo, SP</s2><s3>BRA</s3><sZ>2 aut.</sZ></inist:fA14><country>Brésil</country><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j" type="main">Acta psychiatrica scandinavica. Supplementum</title><title level="j" type="abbreviated">Acta psychiatr. scand., Suppl.</title><idno type="ISSN">0065-1591</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Acta psychiatrica scandinavica. Supplementum</title><title level="j" type="abbreviated">Acta psychiatr. scand., Suppl.</title><idno type="ISSN">0065-1591</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Depression</term><term>Dopamine</term><term>Dysphoria</term><term>Human</term><term>Pleasure unpleasure</term><term>Review</term><term>Reward</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Récompense</term><term>Comportement</term><term>Article synthèse</term><term>Plaisir déplaisir</term><term>Etat dépressif</term><term>Homme</term><term>Dysphorie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: The purpose of this article is to review some of the basic aspects of the dopaminergic system and its role in reward and pleasure behaviour. We also discuss the association between dopamine and unpleasant symptoms that are commonly found in neuropsychiatric disorders and may also be side-effects of neuroleptic drugs. Method: A computer-based search of the literature, augmented by extensive bibliography-guided article reviews, were used to find basic information on the dopamine and the reward systems, and symptoms such as dysphoria, anhedonia and depression. Results: Central dopaminergic neurotransmission is complex, having multiple actions at each level of the mesocorticolimbic reward pathway. The role of dopamine in the reward process was classically associated with the ability to experience pleasure; recent data suggest a more motivational role. Dysfunction of the dopamine transmission in the reward circuit is associated with symptoms such as anhedonia, apathy and dysphoria found in several neuropsychiatric disorders, including Parkinson's disease, depression, drug addiction, and neuroleptic-induced dysphoria. Conclusion: Viewing the dysfunctions of the reward pathways within a broader spectrum and exploring its complex relations with the dopaminergic transmission may help understand the pathophysiology of these neuropsychiatric disorders and lead to a rational development of novel treatments.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Bressan, R A" sort="Bressan, R A" uniqKey="Bressan R" first="R. A." last="Bressan">R. A. Bressan</name></region><name sortKey="Crippa, J A" sort="Crippa, J A" uniqKey="Crippa J" first="J. A." last="Crippa">J. A. Crippa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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